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Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018

doi: 10.3389/fvets.2025.1558440 Received 13 January 2025 Accepted 05 May 2025 Published 05 June 2025 Volume 12 - 2025 Edited by Moyosore Joseph Adegbeye, University of Africa, Nigeria Reviewed by Can Yang, Hengyang Normal University, China Fuquan Yin, Guangdong Ocean University, China Updates Copyright 2025 Qu, Sun, Liang, Nie, Gao, Yuan, Wang and Zhou

Given the importance of H2AX ubiquitination in triggering the DDR, several hydrolases have been shown to regulate the ubiquitination cascade directly or indirectly