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Interestingly, IgE is required to maintain contact sensitivity, although antigen binding to IgE is not involved (Bryce et al., Germinal Center Reactions and the Local B Cell Repertoire)

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Eventually, GABA is removed from the system by converting it into succinate, which is then used in the Krebs cycle in the mitochondria to make ATP.[ref] The enzyme succinic semialdehyde dehydrogenase ( ALDH5A1 gene) is needed to convert GABA into succinate.[ref] Rare genetic mutations in the ALDH5A1 gene cause succinic semialdehyde dehydrogenase deficiency, which decreases the breakdown of GABA

In addition, the industries that process agricultural by-products are potential significant natural antioxidant sources