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Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

Downstream of the receptors, the phosphatidylinositol-3-kinase (PI3K)-Akt and mitogen-activated protein kinase (MAPK) are candidate signalling pathways that mediate FASN expression through the sterol regulatory element-binding protein 1c (SREBP-1c)

When ferroptosis occurs, ferrous ions will start liposome peroxidation through Fenton reaction, which will lead to the accumulation of ROS in cells, thus it is easier to induce strong ERS

The results we obtained in the GSTP1-deficient MCF-7 cell line further support the active role of GSTP1 in HPV-16 E7-related survival, where HPV-16 E7 expression did not protect MCF-7 cells from UV radiation-induced damage, unless GSTP1 was forcibly co-expressed in this model system

doi: 10.1038/s41392-023-01720-0 184 LiJWangH