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In New Hampshire, where access to comprehensive outpatient treatment is expanding, therapy is integrated with pharmacological care to improve engagement and recovery outcomes

Given the reports of complex II inhibition by itaconate and dimethyl malonate (DMM), which increase succinate levels, reduce HIF-1, and limit IL-1 43,59,145 , succinate oxidation is likely a stronger driving force for HIF-1 stabilisation than succinate accumulation per se and requires further investigation

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Guo J-L, Kuang W-M, Zhong Y-F, Zhou Y-L, Chen Y-J, Lin S-M (2020) Effects of supplemental dietary bile acids on growth, liver function and immunity of juvenile largemouth bass ( Micropterus salmoides ) fed high-starch diet

& Nakamura, Y