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Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval

NHEK, renal proximal tubule epithelial cells (RPTEC), human umbilical vein endothelial cells (HUVEC) and human dermal microvascular endothelial cells (HDMEC), using a representative dimeric macrocycle, aMD5-PEG11 (Fig

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doi: 10.1073/pnas.97.2.787