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3.5.5.6 Anxiety, pain, and emotional distress in pets A recurring theme involves treatments leading to or failing to alleviate anxiety, pain, or distress, especially in dogs

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mgi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga J-J, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, et al

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Additionally, systemic side effects associated with sustained growth hormone stimulation include symptoms such as abnormal tissue growth, joint discomfort, and potential enlargement of the heart (cardiomegaly), Roberts says (21)