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To validate these bioinformatics findings, mitochondrial function was assessed in LUAD cells following SLC25A39 knockout (KO)

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HCT 116 cells have been shown to accumulate 7-fold higher levels of copper compared to normal cells 39

The insulin spike from food intake counteracts the GH-releasing signal

Immunoprecipitation studies revealed an increased association of FUS with XRCC1, LigIII, and PARP-1, but not with other base excision repair (BER) proteins in ALS patient-derived iPSC lines carrying FUS mutations (R521H and P525L)