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Therefore, rational combination approaches that concurrently target MDSCs and the complex immunosuppressive network in the TME, together with biomarker-guided patient selection to enable personalized therapies, are critical for clinical success (7)

Acknowledgements AD and JCZ were supported by funds by the National Heart, Lung, and Blood Institute (NHLBI) (R21HL150032, R01HL146442, R01HL149714, R01HL148151)

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IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells