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Ptschke et al., 2025)

It is reported that upon deprotonation of both hydroxyl groups, the two adjacent oxygen atoms act as a bidentate ligand, forming a stable chelate complex with metal ions 33

When phototoxicity prevention through photoprotection is not possible or is impractical, management involves discontinuing the drug or switching to a similar medication with less photosensitizing potential

Across the SURPASS trials documented in the Mounjaro FDA prescribing information, injection-site reactions occurred in approximately 3-7% of participants depending on dose, while true systemic allergic responses (hives spreading beyond the site, facial swelling, breathing difficulty) are rare

For example, it was reported to be an early sign of aging in worms (Wilson et al., 2015)