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Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, reperfusion injury

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5 Hence, iron levels are strictly regulated by a variety of storage, transport and export proteins, including ferritin, transferrin, hepcidin, ferroportin and transferrin receptor 1 (TFR1) to avoid excess iron-derived ROS generation

Excess COX-2 leads to enhanced cell proliferation, blocking apoptosis, changes in cell adhesion processes and angiogenesis, and also increases the metastatic capacity of tumor cells, thus contributing to carcinogenesis [18, 19]