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emphasized that SPRA is characterized by plasma blast expansion, follicular helper T cell (Tfh) infiltration, and the formation of synovial tertiary lymphoid structures (TLS), whereas such adaptive immune markers are notably absent in OA and SNRA ( In summary, although both osteoarthritis and rheumatoid arthritis are associated with the immune system, their immunological mechanisms and treatment approaches differ significantly

This structure receives the anterior branches of the second and third sacral nerves, forming the sacral plexus