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EPIDEMIOLOGY, GENETICS, AND PATHOGENESIS PSC is a rare disease with an incidence rate in northern Europe and the USA of 0.42.0 per 100,000 people per year

At the molecular level, these changes are principally determined by hypoxia-inducible factor (HIF)mediated reshaping of the transcriptional profile, which depends on the extent, duration, and severity of hypoxia and by unfolded protein response (UPR)modified translational program activated in conditions of severe hypoxia/anoxia [4, 5]

The treatment is not painful

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Dysregulation of TrkB receptors and BDNF function by amyloid- peptide is mediated by calpain