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10.3324/haematol.2010.030759 85

Several factors influence the choice of needle and syringe: Type of injection : Intramuscular (IM) or subcutaneous (SC) Gauge of the needle : Diameter of the needle Length of the needle : Determines the depth of injection Volume of the syringe : Determines the amount of B12 to be injected 3

Half-life ~30 min plasma half-life reported in rat models (subcutaneous administration)

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Nature 391(6664):285288 Tang Z et al (2008) Dual MET EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer