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For each of these definitions, and all models apart from the pathway models (E), each measures final model was re-estimated with subgroup-specific intervention effects

In parallel, HFMCDD-fed mice developed moderate to advanced peri-sinusoidal/pericellular fibrosis (F2-3 to F4) with moderate to severe steatosis (grade 2-3) and hepatocyte ballooning (grade 1-2), reflecting human MASLD pathology