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Y.DusfourI.et al (2017)

Hoevenaars FPM, Wopereis S, Plugues M, La Terra P, Batchnarova N

Zhi et al., 2012

Because the hinge and latch hypothesis predicts that the wild-type-mutant heterodimer does not support Nrf2 ubiquitination, a heterozygous missense mutation would result in the 75% reduction of Keap1 activity