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Vit-E could effectively prevent ferroptosis by reducing the Fe 3+ center to inactive Fe 2+ in lipoxygenase (LOX), thereby inhibit enzyme activity of LOX

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Conclusions The current study found that septic patients have higher levels of PyroGlu, lower levels of Glu, and lower erythrocyte GPX activity, suggesting that these biomarkers could be used as an indicator of glutathione depletion