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The Uox KO/huXDH dual-model further achieves a powerful combination of a "hyperuricemia pathological background + human-specific target"

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Retinal pigmented epithelial (RPE) cell malfunction and subsequent photoreceptor degeneration can lead to vision loss, exemplified by conditions such as age-related macular degeneration (AMD) 1

Seiler, M, Peng, S, Agrawal, AA, Palacino, J, Teng, T, Zhu, P, Liu, Y, Zhang, W, Akbani, R, Broom, BM, Ju, Z, Kanchi, RS, Korkut, A, Li, J, Liang, H, Ling, S, Liu, W, Lu, Y, Mills, GB, Uppore Kukkillaya, AR, Weinstein, JN, Zhang, J, Liu, X, Wang, L , Carvalho, AL, Fregnani, JG, Reis, RV, Scapulatempo, CN, Ajani, JA, Behrens, MC, Bondaruk, J, Broaddus, R, Czerniak, BA, Esmaeli, B, Fujimoto, J, Gershenwald, JE, Guo, CC, Lazar, A, Logothetis, CJ, Meric-Bernstam, F, Moran, C, Ramondetta, LM, Rice, DC, Sood, AK, Tamboli, P, Thompson, T, Troncoso, P, Tsao, A, Wistuba, II, von Deimling, A