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The FPOP-LC-MS/MS footprint detected the significant difference in oxidation of peptide 318-329 between Control/his-sumo-GSDME and MeCbl/his-sumo-GSDME group, in which we found a significantly reduced oxidation of M324 upon MeCbl binding

Low back pain is a common concern that affects many individuals in various ways

Dose escalation phase (titration) After the first 4 weeks, if the medication is well tolerated, your healthcare provider will typically increase the dosage to 5 mg once weekly for the next 4 weeks (weeks 5-8)

Real-time qPCR was performed using GoTaq qPCR Master Mix (Promega, A6002) in a QuantStudio 6 Flex thermocycler (Applied Biosystem) or 7900HT Fast Real-Time PCR System (Thermo Fisher)

Mdication concomitante (metformine, omprazole