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J Exp Bot 61:473482 Dubreuil-Maurizi C, Vitecek J, Marty L, Branciard L, Frettinger P, Wendehenne D, Meyer AJ, Mauch F, Poinssot B (2011) Glutathione deficiency of the Arabidopsis mutant pad 2-1 affects oxidative stress-related events, defense gene expression, and the hypersensitive response

Liver transplantation is the only treatment for AATD patients that develop end stage liver disease, though donor organs are quite scarce

3.4 Emerging and experimental approaches for the treatment of PDs Above all, some emerging and experimental approaches for treating PDs include GT, stem cell therapy, neuroprotective agents, and nanomedicine (71)

Glutathione levels are also found to be decreased in central nervous system disorders (such as Alzheimer disease and Parkinson disease), autism, cardiovascular system disorders (atherosclerosis), peripheral vascular disorders, diabetes and its complications, liver disease, acquired immunodeficiency syndrome/human immunodeficiency virus, and chronic obstructive pulmonary diseases

Then, cells were cultured in minimal essential medium alpha (-MEM) supplied with 30 ng/mL macrophage colony-stimulating factor (M-CSF