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56 CicchettiF.LapointeN.Roberge-TremblayA.Saint-PierreM.JimenezL.FickeB

Breen et al

In addition to these shared targets, specific target genes have been reported

The reaction was kept at 0C for 20 minutes, showing complete mono-nitration of the starting material as assessed by HPLC

Results from these multi-scale approaches reveal that cysteines 8 and 83 are the main targets of glutathionylation and oxidation that lead to loss of activity, while cysteine 79 is less vulnerable to oxidation