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At the enzyme level, 5-Amino-1MQ inhibits NNMTs methylation of nicotinamide reducing intracellular 1-MNA levels and diverting nicotinamide back into the NAD+ salvage pathway (via NAMPT-mediated conversion to NMN and subsequently NAD+)

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This is in comparison to traditional PK methodologies, such as non-compartmental analyses, which requires a substantial number of blood collections to accurately estimate PK parameters

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