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Among the most clinically advanced biomimetic delivery systems, allogeneic human adipose mesenchymal stromal cell-derived exosomes (MSC-EVs) have entered Phase I/II clinical trials in patients with mild to moderate AD, where repeated intranasal administration was shown to be safe and well tolerated, with preliminary evidence of cognitive stabilization and reduced hippocampal atrophy

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147,148,149,150 Dietary factors further exacerbate this process