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10.1093/annonc/mdr324 24 FojoT

A systemic reduced oxygen supply affects the whole organism, for example, upon exposure to high altitude environments or hypoxemia associated with obstructive lung disease

Concurrently, these cells increase oxidative phosphorylation to sustain their functional activity under low-glucose conditions, a metabolic adaptation strategy that effectively alleviates nutrient competition with cancer cells [342, 343]