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For instance, taurine-conjugated bile acids stimulate the growth of IECs by activating Src, the epidermal growth factor receptor (EGFR), and ERK pathways

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This phosphorylates and inhibits GFPT1, thereby weakening YAP protein stability and the transcription of its downstream target gene FTH1, ultimately promoting ferritinophagy, lipid peroxidation, and enhanced ferroptosis susceptibility ( Figure 3 Besides glutamine, arginine metabolism also plays a complex role in ferroptosis regulation

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