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doi: 10.1016/j.cbi.2024.111016 179 WangZLiMLiuYQiaoZBaiTYangLet al

Emerging Research Areas Current research directions include: Metabolic disease applications: Obesity and weight management Type 2 diabetes and insulin sensitivity Metabolic syndrome components Age-related metabolic decline Longevity and healthspan: NAD+ optimization strategies Mitochondrial function enhancement Cellular energy metabolism Epigenetic modifications Athletic performance: Exercise metabolism optimization Recovery enhancement Body composition modification Endurance capacity Potential Protocol Refinements As research advances, dosing protocols may evolve: Personalized dosing algorithms: Genetic markers for NNMT activity Metabolic phenotype-based protocols Real-time biomarker monitoring Adaptive dosing systems Combination therapies: Synergistic compound identification Optimized multi-compound protocols Sequential vs

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Lancet 397 , 17361748 (2021)

Direct clinical evidence is limited