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Fundam Clin Pharmacol (2018) 32:2650

Bai Y, Lu H, Lin C, Xu Y, Hu D, Liang Y, Hong W, Chen B (2016) Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis

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The consequent changes in the ATP/ADP ratio could influence AMPK phosphorylation, thereby decelerating the tricarboxylic acid cycle (evidenced by reductions in citrate, -ketoglutarate and malate) and impairing glutathione synthesis (33, 34)