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This resulted in the selection of leucovorin and dyclonine, two FDA-approved compounds, which we demonstrated to have brain repair and pro-oligodendrogenic activities in both preterm birth brain injury and adult demyelination mouse models, with leucovorin demonstrating broader beneficial effects

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Moreover, the multidrug resistance protein-1 (MDR1, ABCB1), which transports organic cations, and the multidrug resistance protein-2 (MRP2, ABCC2), which regulates the independent flow of bile salts by excreting glutathione are involved [20]