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Moreover, curcumin interferes with signaling cascades such as mitogen-activated protein kinases (MAPKs) and AP-1, and it can activate peroxisome proliferator-activated receptor-gamma (PPAR-), all of which further skew cells toward an anti-inflammatory phenotype ( In addition to dampening proinflammatory signals, curcumin modulates the immune response

To examine the impact of dyclonine and leucovorin on proliferation, brains were analyzed at P13, corresponding to the end of the treatment period, after EdU administration one hour before sacrifice to label cells in S-phase

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