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Synergistic impact of endurance training and intermittent hypobaric hypoxia on cardiac function and mitochondrial energetic and signaling

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Metabolic dysfunction-induced iron surplus may escalate the severity of NAFLD, as indicated by the presence of hepatic iron deposition in affected individuals, with the amelioration of hepatic injury following iron removal [177, 178]

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To date, CB-839 has completed phase I and phase I/II dose-escalation studies as monotherapy and advanced into phase Ib/II combination trials and phase II biomarker-driven basket studies, primarily enrolling patients with KEAP1/NRF2-, NF1 (neurofibromin 1)-altered, or LKB1 (liver kinase B1)-altered solid tumors (e.g., NCT03047993, NCT03875313, NCT03872427)