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The -syn knockout mice or mice administered a competing peptide targeting ser129 resist chronic hypoxia-induced cognitive impairment The above studies showed that chronic hypoxia-induced cognitive impairment in mice and was accompanied by abnormal changes in -syn

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Monitor progress and adjust treatment as needed

Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

CMMAI-RI is currently overseeing at least 30 major projects under RPJMN 2020-2024, including land-based infrastructure projects (Sambodo et al., 2023a)