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Benipal, A

doi: 10.1007/s43032-021-00743-8

It is counterintuitive, but one of the cleaner randomized Alzheimers trials found exactly that: a 10 mL daily dose improved both cognition and global function, while higher 30 and 60 mL doses helped global function but not cognition, a reversed-U pattern where more was not better

As more data has come out, basing treatment off of a MTHFR mutation has become more suspect, with the majority in the medical and functional medicine space currently viewing MTHFR mutations as having minimal clinical information without factoring in other clinical and laboratory risk factors

Split dosing Some researchers divide their weekly dose into two injections