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[4] Function [edit] Aspartate transaminase catalyzes the interconversion of the natural amino acid, L-aspartic acid and -ketoglutaric acid to give oxaloacetic acid and L-glutamic acid.: As a prototypical transaminase, AST relies on PLP (vitamin B 6 ) as a cofactor to transfer the amino group from aspartate or glutamate to the corresponding ketoacid

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Research in mice lacking HO-1 has revealed the overall function of HO-1 in restoring functional macrophages, maintaining iron balance within tissues, and increasing tolerance to oxidative stress conditions [98,99,100]