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the effect may also complement insulin in steadying blood glucose [7]

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In fact, CBDs anticancer activity is both receptor-dependent and receptor-independent, involving mechanisms such as the induction of endoplasmic reticulum (ER) stress, autophagy, apoptosis, and the inhibition of key signaling pathways like PI3K/AKT/mTOR and MAPK/ERK [174]

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Preclinical and clinical studies in glioblastoma showed that when the tumor becomes resistant to anti-VEGF, there is an increase of the Ang-2 level