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He states: "The dog, and in particular the CKCS breed, represents a model to further study 5HT and TGF-B mechanisms and to test novel therapies." His list includes: "One example is the Cavalier King Charles Spaniel (CKCS) breed, in which death due to heart disease comprises over 30% of all causes of death." "Beginning at the age of 3 years, the yearly incidence of MMVD in the CKCS is approximately 7% and rises to as high as 15% in subsequent years, such that virtually all dogs exhibit disease by the age of 10 years." "CKCS, a breed with extremely high prevalence of MMVD, are reported to have particularly increased serum 5HT levels." "5HT in platelet rich plasma was higher in healthy CKCS, as well as both CKCS and mixed breed dogs with MMVD vs