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Currently, SA--gal activity is considered one of the most crucial markers of cellular senescence [26]

The ratio of reduced glutathione (GSH) to its oxidized form (GSSG) dropped from 18.9 in young adults to 7.4 in elderly subjects

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However, clinical practitioners often recommend a "start low and go slow" approach, particularly for patients with severe chronic illness who may be highly sensitive to new supplements or prone to detoxification reactions (Herxheimer reactions)