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It is suggested that volitional changes in breathing patterns can activate primary control centers for descending pain/cold stimuli in periaqueductal gray, initiating a stress-induced analgesic response mediated by eCB/endorphin release

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Additionally, patients could worsen during the study and still be classified as recovered and the study was unblinded with subjective outcomes

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Sajith, M., Pawar, A., Bafna, V

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Alexander, A., Patel, R

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Jackson KE, Klonis N, Ferguson DJ, Adisa A, Dogovski C, Tilley L

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