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Acknowledgements This work was supported by the UKRI FLF/MRC Award MR/V026283/1 (O.U.), NIH/NIGMS R35 GM118047 (H.A.), NIH/NCI R01 CA237272 (A.M.L.), NIH/NCI R01 CA233562 (A.M.L.), a 2018 Prostate Cancer Foundation Challenge Award (A.M.L.), a Prostate Cancer Foundation Young Investigator Award (A.M.L.), and Andy North and Friends (A.M.L.)