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To view a copy of this licence, visit About this article Cite this article Rettie, S.A., Juergens, D., Adebomi, V

& Muoz-Cnoves, P

Through a series of enzyme-driven reactions, Phase 1 alters the structure of toxins via: Oxidation introducing oxygen to increase chemical reactivity Reduction removing oxygen to alter molecular configuration Hydrolysis breaking chemical bonds using water Hydration adding water molecules to facilitate further processing Dehalogenation removing halogen atoms such as chlorine or bromine The purpose of Phase 1 is not elimination, but activation

Absorbance was measured at 450 nm

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