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Taken together, these findings suggest that APR-246 could induce tumor cell death through both reactivation of mutant p53 and inhibition of cellular thiol-dependent redox system proteins (GPX4, TXNDR1, GRX1), providing novel combinatorial strategies for AML therapy

Stability studies may assess resistance to oxidation, reduction or hydrolysis under standardized laboratory protocols

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Dietz PM, Rose CE, McArthur D, Maenner M (2020) National and state estimates of adults with autism spectrum disorder

Clinical evidence, however, is currently lacking to support the use of this diet for the treatment or prevention of cancer