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Since the protective action of melatonin was accompanied by increased mucosal blood flow and could be attenuated by pretreatment with COX or NO inhibitors such as indomethacin or L-NAA, respectively, and by pretreatment with capsaicin in neurotoxic dose (125 mg/kg) to inactivate the sensory nerves (45), we propose that melatonin protects esophageal mucosa by increasing the mucosal blood flow due to the enhancement of prostaglandin, NO and CGRP release in the mucosa

Testing was conducted using the remaining subgroup, and ROC curves using the pROC 87 package were determined to obtain AUCs

The end result has two important features: 1) all proteins retain only their primary structure and 2) all proteins have a large negative charge which means they will all migrate towards the positve pole when placed in an electric field

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