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Because they're consumed in such high quantitiesthe omega:3 to omega-6 intake of the Western diet is heavily skewed towards omega-6sit can create low-grade systemic inflammation and serves as a breeding ground for disease 3, 4

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It decreases COX-2 gene expression, reduces myeloperoxidase activity, and lowers pro-inflammatory cytokines including IL-6 and TNF-alpha

An example is the enzyme hRIDA deaminase, whose succinylation reduces activity and inhibits cell proliferation, which may have implications in cancer [63]