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Pt 4Brain

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53 Fluctuating hormone levels, in particular, have been correlated with increased pain sensitivity

Therefore, our findings showing that ubiquitylated IL-1, akin to the IL-1 K133A or D129A mutants, is inefficiently cleaved by Caspase-1 raises the interesting possibility that IL-1 K133 ubiquitylation impacts the integrity of the K133:D129 electrostatic interaction to limit caspase-1 processing

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