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Furthermore, therapeutic modulation of the expression or function of this gene may be useful in the treatment of neurologic disorders, such as Alzheimer's disease, Parkinson's disease, schizophrenia, multiple sclerosis, stroke and epilepsy

Organ-Specific Concerns Certain nutrients place strain on the kidneys or heart if not properly dosed or screened

Neuroinflammation Neuroinflammation is a critical factor in the pathogenesis of PD

Key Insights MTHFR is a single enzyme within the larger one-carbon metabolism network, which includes the folate cycle, methionine cycle, and transsulfuration pathway (2,5,6) SAMe (S-adenosylmethionine) provides allosteric feedback regulation of MTHFR so more methyl donors is not always better (1,6) If methyl donors trigger insomnia, agitation, or anxiety, it may be a sign the approach is mismatched to your current foundations (3,4) Context matters: sleep, HPA-axis stress load, minerals, thyroid signalling, and gut microbiome health can influence how you experience methylation support (12,14,16) Citable Takeaways Bhatia et al

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