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This model dependence raises concerns about the translatability of findings, as mechanisms identified in acute models may not apply to chronic, clinically relevant RF

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However, the evidence, formulation, and regulatory status vary

35 For people unable to stop antidepressants in a traditional taper, Dutch researchers have reported success with a much more gradual hyperbolic taper, facilitated with specialized dose tapering strips. For example, 608 people mostly taking venlafaxine and paroxetine used 28-day tapering strips to reduce drug doses hyperbolically over schedules of 4 to 20 weeks