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Ethics declarations Ethics Approval and Consent to Participate In-vivo pharmacokinetic study was performed as per the standard protocol of the Committee for the Purpose of Control and Supervision of Experiments on Animals (Protocol approval no

However, this leads to a different conformational change as compared to 17-estradiol and the hydrophobic pocket is not sealed by helix-12 8

Interestingly, HIV infection is associated with an increased risk of pituitary gland stroke and pituitary lymphoma, possibly leading to hypopituitarism, one of the effects of which is infertility