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the major mechanisms by which the drug is cleaved from the antibody include hydrolysis in the acidic pH of the lysosomes (hydrazones, acetals, and cis-aconitate-like amides), peptide cleavage by lysosomal enzymes (the cathepsins and other lysosomal enzymes), and reduction of disulfides

Secondary endpoints were defined as pharmacodynamics and pharmacokinetic parameters including maximum serum concentration, time to maximum concentration, half-life, plasma clearance, and volume of distribution, as well as exploratory parameters including bodyweight, glycemic control, and overall hormone profile

Proc Natl Acad Sci USA 98: 51165121 ValleCasuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, AvettandFenoel V, Boufassa F, Sitbon M et al (2019) Cellular metabolism is a major determinant of HIV1 reservoir seeding in CD4 T cells and offers an opportunity to tackle infection

BresellA.WeinanderR.LundqvistG.RazaH.ShimojiM.SunT