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Likewise, reestablished blood flow may certainly contribute to the rapid recovery effect noted, BPC 157 directly protects endothelium [47,56], alleviates the peripheral vascular occlusion disturbances [49,50,51,52,53,54,55,56,57,58,59,60], rapidly activating alternative bypassing pathway [49,50,51,52,53,54,55,56,57,58,59,60]

This restoration is achieved by reducing drug efflux (downregulating MRP2 levels), inhibiting GSH-related detoxification, and suppressing nucleotide excision repair (NER)-mediated DNA repair

This study is a critical review carried out through database searches, synthesis of the evidence, and critical interpretation of the findings

33 , e13983 (2021)

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