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In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates

We run the GSH program and the APAP program together - they share the substrate GSH, which is drawn down by the overdose and replenished by the GSH synthesis pathway

M.AlikunjuS.SzlachetkaA

Musante et al

Standard protocols typically involve 0.25 to 0.5 mg daily for four to eight weeks, with some aggressive protocols starting at higher doses before tapering