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In a 12-week clinical study involving 71 women, GHK-Cu cream was observed to increase skin density and thickness while reducing fine lines

Biological biomolecules based on gene expression, epigenetic alterations, microRNA profiles, protein phosphorylation and cytokine signatures can contribute to the selection of subsets of these patients for specific natural agents, monitoring in vivo biological efficacy and potential synergistic (or antagonistic) interactions with medical therapies (223)