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In both WT and OSKM mice, the microbial diversity as measured by the Shannon index decreased following 7 days of doxycycline treatment, with the most profound loss of diversity occurring in reprogrammed mice (Extended Data Fig

A total of 10 grams per day were given in 4 divided doses

Avoid rapid intravenous infusion Observe vital signs during administration Ensure availability of emergency response measures Glutathione injection should only be administered by trained healthcare professionals familiar with sterile technique and infusion protocols

Therefore it is not surprising that ROS would modulate an NF-B response and that NF-B target genes would attenuate ROS to promote survival